DENTON, Texas — Groundbreaking research conducted by Constance B. Hilliard, a professor at the University of North Texas, has shed light on potential genetic factors contributing to health problems prevalent among African American populations. Hilliard’s findings, detailed in her book “Ancestral Genomics: African American Health in the Age of Precision Medicine,” published by Harvard University Press, suggest that unique genetic variations may be responsible for conditions such as hypertension and kidney disease.
Hilliard’s research was sparked by a personal medical experience in Japan in 2008. After being diagnosed with renal failure due to elevated creatinine levels by a Japanese doctor, a subsequent evaluation by an American doctor revealed no such condition, as the creatinine levels were deemed normal for Black Americans. This discrepancy led Hilliard to investigate further, uncovering genetic variations linked to West African ancestry.
Her interdisciplinary research identified that individuals of West African descent are more likely to possess G1 and G2 variants of the APOL1 gene, which are adaptations to historically low-salt environments. These gene variants allow for efficient sodium absorption, which, while advantageous in salt-scarce regions, can lead to health issues in modern diets high in sodium.
Historical accounts, such as manuscripts from Timbuktu and the medieval empires of Mali and Songhay, reveal that West African elites engaged in extensive trade, exchanging gold for salt. This historical context provided a foundation for understanding the genetic adaptations Hilliard explored.
Statistics from the National Institutes of Health highlight the impact of these genetic factors: Black Americans are three to four times more likely to die from kidney failure and 75% of Black Americans aged 55 and older suffer from high blood pressure. Hilliard’s research suggests that those carrying the G1 and G2 variants need significantly less dietary sodium than the average intake of 3,400 milligrams per day in the U.S. Reducing sodium intake could help mitigate the prevalence of hypertension and kidney disease in this population.
Hilliard emphasized the potential impact of these findings on Black health, stating, “Few African American families are without members or friends who have not suffered from APOL1-triggered diseases such as salt-sensitive hypertension and kidney failure. But the knowledge that these disorders may be preventable in some cases could be a Black health game changer.”
Hilliard’s work provides a crucial step towards precision medicine tailored to genetic backgrounds, offering hope for better health outcomes in African American communities.
